My interest in the healing properties of plants and mushrooms began in childhood. I spent every summer in a small village in southern Russia, where my grandparents lived. My grandmother gathered wild herbs and mushrooms from the surrounding forest and mountains, dried them, and used them throughout the year as both spices and medicines. As her eyesight failed, I read books on medicinal herbs aloud to her in the evenings; her knowledge grew, and so did mine.
Biology and chemistry became my favorite subjects, and I went on to major in biochemistry. After earning my M.S., I completed doctoral studies at the Institute of Plant Physiology in Moscow and the National Institute for Basic Biology in Okazaki, Japan, followed by academic research in Naples, Italy, and at The Scripps Research Institute in La Jolla, California.
From 2002 I worked for several biotech startups developing biopharmaceuticals. In 2012 I started my own consulting practice, bringing together the threads that had run through my life: herbs, science, medicine, and flavor.
Since then I have helped startups and established companies bring more than 100 commercially successful products to market.
Malakhov MP, Aschenbrenner LM, Smee DF, Wandersee MK, Sidwell RW, Gubareva LV, Mishin VP, Hayden FG, Kim DH, Ing A, Campbell ER, Yu M, Fang F. (2006) Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infection. Antimicrob Agents Chemother.; 50:1470-1479.
Malakhov MP, Mattern MR, Malakhova OA, Drinker M, Weeks SD, Butt TR. (2004) SUMO fusions and SUMO-specific protease for efficient expression and purification of proteins. J Struct Funct Genomics; 5:75-86.
Malakhova O, Yan M, Malakhov M, Yuan Y, Ritchie K, Kim KI, Peterson L, Shuai K, Zhang DE. (2003) Protein ISGylation regulates the JAK-STAT signaling pathway. Genes Dev.; 17: 455-460.
Malakhov MP, Kim KI, Malakhova OA, Jacobs BS, Borden EC, Zhang DE. (2003) High-throughput immunoblotting. ISG15 modifies regulators of signal transduction. J Biol Chem.; 278: 16608-16613.
Benvenuto G, Formiggini F, Laflamme P, Malakhov M, Bowler C. (2002) The photomorphogenesis regulator DET1 binds the amino-terminal tail of histone H2B. Curr Biol.; 12: 1529-1534.
Ritchie KJ, Malakhov MP, Hetherington CJ, Zhou L, Little MT, Malakhova OA, Sipe JC, Orkin SH, Zhang DE. (2002) Dysregulation of protein modification by ISG15 results in brain cell injury. Genes Dev.; 16: 2207-2212.
Malakhov MP, Malakhova OA, Kim KI, Ritchie KJ, Zhang DE. (2002) UBP43 specifically removes ISG15 from conjugated proteins. J Biol Chem.; 277: 9976-9981.
Malakhova O, Malakhov M, Hetherington C, Zhang DE. (2002) Lipopolysaccharide activates the expression of UBP43 via interferon regulatory factor 3. J Biol Chem.; 277: 14703-14711.
Malakhov M, Bowler C. (2001) Phytochrome and regulation of photosynthetic gene expression. Regulation of Photosynthesis, E-M Aro and B Andersson (eds), Kluwer, pp. 51-66.
Malakhov MP, Malakhova OA, Murata N. (1999) Balanced regulation of expression of the gene for cytochrome cM. FEBS Lett.; 444: 281-284.
Malakhov M, Wada H, Los D, Murata N. (1996) The coxD gene for heme O synthase in Synechocystis. Biochim Biophys Acta; 1273: 84-86.
Malakhov MP, Los DA, Wada H, Semenenko VE, Murata N. (1995) Characterization of the murF gene of the cyanobacterium Synechocystis sp. PCC 6803. Microbiology (UK); 141: 163-169.
Malakhov MP, Wada H, Los DA, Semenenko VE, Murata N. (1994) A new type of cytochrome c from Synechocystis PCC6803. J. Plant Physiol.; 144: 259-264.
Malakhov MP, Wada H, Los DA, Sakamoto T, Murata N. (1993) Structure of a cyanobacterial gene encoding the 50S ribosomal protein L9. Plant Mol Biol.; 21: 913-918.
Butt TR, Weeks S, Tran H, Malakhova OA, Malakhov MP. Methods and compositions for protein expression and purification. US Patents 7,060,461 and US Patent 7,220,576.
Fang F, Malakhov M. Novel class of therapeutic protein based molecules. US Patent 7,645,448.
Fang F, Malakhov M. Class of therapeutic protein based molecules. US Patent 8,722,869.
Butt TR, Malakhova OA, Malakhov MP. Methods and compositions for enhanced protein expression and purification. US Patent 7,655,413.
Malakhov MP, Fang F. Technology for preparation of macromolecular microspheres. US Patent 8,623,419.
Malakhov MP, Li T. Microparticle Formulations for Delivery to the Lower and Central Respiratory Tract and Methods of Manufacture. US Patent 9,700,602.
Fang F, Wurtman D, Moss R, and Malakhov MP. Methods, compounds, and compositions for treatment and prophylaxis in the respiratory tract. US Patent 8,398,971.
Malakhov MP. Devices and systems for supporting a user. US Patent 8,713,729.
Malakhov MP. System, method and apparatus to prevent and treat a disease by optimization of sleep posture and assisted rollovers. US Patent 11,622,896.